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AM-2201, were identified, with the National Forensic Laboratory Information System containing 220 THJ-2201 reports. Because of numerous adverse events, the Drug Enforcement Administration listed THJ-2201 as Schedule I in January 2015.
We used high-resolution mass spectrometry (HR-MS) (TripleTOF 5600+) to identify optimal metabolite markers after incubating 10 μmol/L THJ-018 and THJ-2201 in human hepatocytes for 3 h. Data were acquired via full scan and information-dependent acquisition triggered product ion scans with mass defect filter. In silico metabolite predictions were performed with MetaSite and compared with metabolites identified in human hepatocytes.
Thirteen THJ-018 metabolites were detected, with the major metabolic pathways being hydroxylation on the N-pentyl chain and further oxidation or glucuronidation. For THJ-2201, 27 metabolites were observed, predominantly oxidative defluorination plus subsequent carboxylation or glucuronidation, and glucuronidation of hydroxylated metabolites. Buy THJ-018 Synthetic Cannabinoid Online
Dihydrodiol formation on the naphthalene moiety was observed for both compounds. MetaSite prediction matched well with THJ-018 hepatocyte metabolites but underestimated THJ-2201 oxidative defluorination. Buy THJ-018 Synthetic Cannabinoid Online
With HR-MS for data acquisition and processing, we characterized THJ-018 and THJ-2201 metabolism in human hepatocytes and suggest appropriate markers for laboratories to identify THJ-018 and THJ-2201 intake and link observed adverse events to these new synthetic cannabinoids. Buy THJ-018 Synthetic Cannabinoid Online
Synthetic cannabinoids (SCs) interact with endogenous cannabinoid receptors and elicit cannabimimetic effects similar to those of Δ9-tetrahydrocannabinol (1, 2). SC3 abuse causes serious toxicities, including acute kidney injury, myocardial infarction, and death (3, 4). Buy THJ-018 Synthetic Cannabinoid Online
Despite these health hazards, SC intake persists. Many SCs (e.g., JWH018, JWH-073, AKB48, and XLR-11) have been scheduled in the US, Japan, and most European countries; however, more structurally diverse compounds continuously emerge. Buy THJ-018 Synthetic Cannabinoid Online